![]() ![]() When hit with the second injection, the immune system is already primed. More users of V-safe, the CDC's tool to report vaccine side effects, reported side effects within a week of getting their second shot compared to the first, according to a Jan. The Moderna and Pfizer vaccines are administered in two doses, spaced apart by about 28 and 21 days, respectively. Why some people experience more severe side effects after the second dose "All of a sudden, you have a lot of new RNA that the cell didn't make," Donna Farber, PhD, an immunologist at New York City-based Columbia University, told The Atlantic. The mRNA itself may provoke a reaction from the immune system. "A number of things happen with regard to inflammation, but it's really a sign that our immune system is recognizing that there's a foreign protein in our body and is preparing to fight it and get rid of it," William Moss, MD, epidemiologist and executive director of the International Vaccine Access Center at Baltimore-based Johns Hopkins University, told WNYW. Inflammation as an immune response can result in redness, swelling and tenderness at the injection site, along with broader systemic responses, such as fever, headache, muscle aches, joint pain or fatigue, reports Fox's WNYW. Sometimes after vaccination, the process of building immunity can cause symptoms, though all side effects should go away within a few days. Side effects from the vaccine are normal signs the body is building protection against COVID-19, according to the CDC. Why some individuals experience side effects after receiving the vaccine mRNA vaccines work to induce an immune response against the spike protein, primarily through antibodies, so when a virus is detected in the future, it can be fought off more swiftly, according to The Atlantic. There are spike proteins on the surface of SARS-CoV-2, the virus that causes COVID-19, which help the virus bind to other cells and replicate. Side effects appear to be more common after the second dose for both Pfizer-BioNTech and Moderna COVID-19 vaccines.īoth vaccines have received FDA emergency use authorization, and both companies' clinical trials recorded participants experiencing side effects.īut why is the second dose more likely to be tied to more side effects?īoth Pfizer and Moderna vaccines are mRNA vaccines, which means they use a copy of a natural chemical - messenger RNA - to produce an immune response. 50 community hospital cfos to know | 2022.83 community hospital ceros to know | 2022.260+ healthcare revenue cycle management companies to know | 2022.50 chief digital officer innovators to know | 2022.75 black healthcare leaders to know| 2022.150 top places to work in healthcare | 2022.Past Issues - Becker's Clinical Leadership & Infection Control.Current Issue - Becker's Clinical Leadership & Infection Control.Becker's Cardiology + Heart Surgery Podcast.Becker's Ambulatory Surgery Centers Podcast. ![]()
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